Innovation in Endocrinology: Encaleret in ADH1 - Treating the root cause
In the rapidly evolving field of endocrinology, staying abreast of the latest scientific advancements and innovative treatments is essential for healthcare professionals and researchers. The ESE ‘Innovation in Endocrinology’ webinars are designed to highlight groundbreaking developments in endocrine science and practice.
The ongoing developments and progress in research, disease understanding, diagnosis, treatment and long-term care and outcomes warrant the specific focus offered by this webinar model. The webinars are free to attend and will be recorded, with recordings being made available for on demand viewing via the ESE website.
About the topic
ADH1 is caused by pathogenic variants in the calcium-sensing receptor gene (CASR), which senses the level of calcium in the body and regulates the amount of calcium in the blood through its effects on the parathyroid glands, the kidney, and bone. Historically, ADH1 management has relied on symptomatic treatment with calcium supplements and active vitamin D, which do not address the underlying pathophysiology. Encaleret could become the first targeted oral therapy for ADH1 directly addressing the underlying cause, rather than just managing calcium levels with supplements and active vitamin D.
This webinar will provide endocrinologists with an opportunity to understand mechanism-based therapy targeting the CaSR and translate recent efficacy data into clinical practice implications for their patient populations.
Encaleret in ADH1 - Treating the root cause
Welcome and introduction to the topic
Chair: Andrea Palermo (Italy)
Understanding ADH1 and current treatment challenges
Speaker: Lars Rejnmark (Denmark)
CaSR targeted therapy in ADH1 – Phase 3 evidence and implications for clinical practice
Speaker: Sandrine Lemoine (France)
Moderated discussion and Q&A
Chair: Andrea Palermo (Italy)
Webinar closing
Chair: Andrea Palermo (Italy)
Please note: ESE does not permit attendance of sanctioned individuals or individuals from sanctioned institutions at any ESE events. Please click here to see ESE's Sanctions Policy
Once you have registered for the course, you will be sent a confirmation email. In the week leading up to the webinar you will receive another email from the ESE Office (via Zoom) asking you to confirm your name, email and acknowledge that the webinar is being recorded. An email with the link to access the live webinar will then be sent to you directly from Zoom.
Sessions will be carried out of Zoom, so please ensure that you are able to access Zoom on your University/institution computer.
The recording of the webinars will be available on the ESE website approximately 3 weeks after the webinar has taken place.
Information to follow shortly.
Keep up to date with the latest ESE News >>
19/11/2026