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European Society of Endocrinology Clinical guideline for the management of hyponatraemia


Goce Spasovski, Raymond Vanholder, Bruno Allolio, Djillali Annane, Steve Ball, Daniel Bichet, Guy Decaux, Wiebke Fenske, Ewout J Hoorn, Carole Ichai, Michael Joannidis, Alain Soupart, Robert Zietse, Maria Haller, Sabine van der Veer, Wim Van Biesen, Evi Nagler on behalf of the Hyponatraemia Guideline Development Group

Developed By:

The European Society of Endocrinology, the European Society of Intensive Care Medicine (ESICM), and the European Renal Association – European Dialysis and Transplant Association.


The purpose of this Clinical Practice Guideline was to provide guidance on the diagnosis and treatment of adult individuals with hypotonic hyponatraemia. It was designed to provide information and assist in decision-making related to this topic and was meant to support clinical decision-making for any health care professional dealing with hyponatraemia, i.e. general practitioners, internists, surgeons and other physicians dealing with hyponatraemia in both an outpatient and an in-hospital setting. The guideline was also developed for policymakers for informing standards of care and for supporting the decision-making process.